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The complex molecular epileptogenesis landscape of glioblastoma

1 Aug 2024

Abstract excerpt

The cortical microenvironment surrounding malignant glioblastoma is a source of depolarizing crosstalk favoring hyperexcitability, tumor expansion, and immune evasion. Neosynaptogenesis, excess glutamate, and altered intrinsic membrane currents contribute to excitability dyshomeostasis, yet only half of the cases develop seizures, suggesting that tumor and host genomics, along with location, rather than mass...

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PMID: 39168100
DOI: 10.1016/j.xcrm.2024.101691

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