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Glioblastoma Tumors with Decelerated Epigenetic Aging Are Characterized by Glutamatergic Neuronal Activity and Stemness

2026-08-31

Abstract excerpt

<h4>Introduction: </h4> Gliomas integrate into neural circuits and heighten neuronal excitability, engaging in bidirectional communication whereby neuronal activity promotes tumor growth and proliferation. Aging reshapes the brain microenvironment through extracellular matrix changes, altered secretory factors, and immune dysfunction, creating conditions permissive to tumorigenesis and limiting immunotherapy effic...

Identifiers and source

Literature Corpus work
fb31123b-771c-5bf9-a1f8-fcc7a582fe80
DOI
10.64898/2026.08.29.747960
Open publication

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Glioblastoma Tumors with Decelerated Epigenetic Aging Are Characterized by Glutamatergic Neuronal Activity and StemnessDOI 10.64898/2026.08.29.747960
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