Article

Region-specific human brain organoids reveal synaptic and cell state drivers of glioblastoma invasion

2025-10-15

Abstract excerpt

<h4>ABSTRACT</h4> Glioblastoma (GBM) is a highly heterogenous and malignant brain tumor, in part because it disrupts normal brain circuits to fuel its own growth and invasion. Thus, there is a need to identify the molecular features of invasive GBM cells and their regulators in the neural microenvironment. To address this in a fully human model, we engrafted patient-derived GBM cells (total n= 15 independent sam...

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Literature Corpus work: 610eef8b-609a-51df-96ac-4d9ef146481c
DOI: 10.1101/2025.10.15.682580

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