Article

Glutamatergic neuron-tumor synapses shape human glioblastoma cell states through radial glia plasticity

2026-05-15

Abstract excerpt

Glioblastoma (GBM) is a devastating primary brain tumor with remarkable inter- and intra-tumoral heterogeneity. GBM cells assume a spectrum of neurodevelopmental-like phenotypes and co-opt normal neurophysiological processes, which include synaptic integration with their neuronal microenvironment. This is mediated by neuron-tumor synapses (NTS) that predominantly involve glutamatergic receptors, which drive calciu...

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Literature Corpus work: 0d269941-5e8f-5fbe-a554-5fe54596a6b0
DOI: 10.64898/2026.05.14.725216

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