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Integration of spatial transcriptomics with immunofluorescence staining reveals spatial heterogeneity and plasticity of astrocytes in experimental glioblastomas

2024-10-12

Abstract excerpt

Astrocytes comprise ∼50% of all brain cells and present distinct morphological, molecular and functional properties in different brain regions. In glioblastoma (GBM), an aggressive primary brain tumour, tumour-associated astrocytes (TAAs) become activated and exhibit different transcriptomic profiles, morphology and functions supporting disease progression. Heterogeneity and specific roles of TAAs within various r...

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Literature Corpus work
b6795252-73aa-56f0-b4e3-4c649ea2f462
DOI
10.1101/2024.10.11.617740
Open publication

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Integration of spatial transcriptomics with immunofluorescence staining reveals spatial heterogeneity and plasticity of astrocytes in experimental glioblastomasDOI 10.1101/2024.10.11.617740
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