Article

Glutamatergic Neuron–Meningioma Synapse Interaction Promotes Brain-Invasive Tumor Growth

2026-08-27

Abstract excerpt

Meningiomas are typically extra-axial, separated from brain parenchyma by a distinct interface, but an aggressive subset breaches this boundary and invades the brain, forming a brain-tumor interface (BTI). Whether this invasion enables direct communication between meningioma cells and neurons was unknown. Here, we identified putative neuron–meningioma synapses by electron microscopy in human specimens, more abunda...

Topics

Open a Topic to create a Post that cites this publication.

Uncategorized literature

Identifiers and source

Literature Corpus work: 9d23a95f-956c-586d-a403-e8cb56ace3cf
DOI: 10.64898/2026.08.26.747240

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

Glutamatergic Neuron–Meningioma Synapse Interaction Promotes Brain-Invasive Tumor GrowthDOI 10.64898/2026.08.26.747240Read

Glutamatergic neuron-tumor synapses shape human glioblastoma cell states through radial glia plasticitySemantic proximity Read

Direct excitatory synapses between neurons and tumor cells drive brain metastatic seeding of breast cancer and melanomaSemantic proximity Read

Region-specific human brain organoids reveal synaptic and cell state drivers of glioblastoma invasionSemantic proximity Read

Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracingSemantic proximity Read

Dysregulated Microglial Synaptic Engulfment in Diffuse Midline GliomaSemantic proximity Read

Spatial synaptic connectivity underlies oligodendroglioma evolution and recurrenceSemantic proximity Read

Functional synapses between small cell lung cancer and glutamatergic neuronsSemantic proximity Read

A panel of synapse assembly genes as a biomarker for GliomasSemantic proximity Read

GABAergic neuron-to-glioma synapses in diffuse midline gliomasSemantic proximity Read

Glioblastoma cells imitate neuronal excitability in humansSemantic proximity Read

Remote neuronal activity drives glioma infiltration via Sema4fSemantic proximity Read

Transcription factor-based gene therapy to treat glioblastoma through direct neuronal conversionSemantic proximity Read