Article

Glioma synapses recruit mechanisms of adaptive plasticity

2021-11-04

Abstract excerpt

The nervous system plays an increasingly appreciated role in the regulation of cancer. In malignant gliomas, neuronal activity drives tumor progression not only through paracrine signaling factors such as neuroligin-3 and brain-derived neurotrophic factor (BDNF) 1–3 , but also through electrophysiologically functional neuron-to-glioma synapses 4–6 . Malignant synapses are mediated by calcium-permeable AMPA (α-am...

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Literature Corpus work: 0bcf0dc3-6b5c-57aa-9324-07bea9590e8f
DOI: 10.1101/2021.11.04.467325

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