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Article

Differential splicing of neuronal genes in a Trem2*R47H mouse model mimics alterations associated with Alzheimer's disease.

BMC genomics - 4 Apr 2023

Pandey Ravi S, Kotredes Kevin P, Sasner Michael, Howell Gareth R, Carter Gregory W

Abstract excerpt

BACKGROUND: Molecular characterization of late-onset Alzheimer's disease (LOAD), the leading cause of age-related dementia, has revealed transcripts, proteins, and pathway alterations associated with disease. Assessing these postmortem signatures of LOAD in experimental model systems can further elucidate their relevance to disease origins and progression. Model organisms engineered with human genetic factors...

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PMID: 37016304
DOI: 10.1186/s12864-023-09280-x
PMCID: PMC10074678

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