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MTHFR*677C>T produces distinct prodromal disease signatures in a mouse model of late-onset Alzheimer's disease

2026-08-28

Abstract excerpt

<h4>Background: </h4> Late-onset Alzheimer's disease (LOAD) comprises more than 95% of all AD cases. Transgenic, overexpression animal models have off target side effects, do not effectively produce the heterogeneity observed clinically in LOAD patients, and are therefore not best suited for preclinical therapeutic development. The Model Organism Development and Evaluation for Late-onset Alzheimer's Disease (MODEL...

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Literature Corpus work: 7fae8e31-0405-54c0-8f3f-afa2cbffe690
DOI: 10.64898/2026.08.25.746973

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