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Article

In vivo validation of late-onset Alzheimer's disease genetic risk factors.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jul 2024

Sasner Michael, Preuss Christoph, Pandey Ravi S, Uyar Asli, Garceau Dylan, Kotredes Kevin P, Williams Harriet, Oblak Adrian L, Lin Peter Bor-Chian, Perkins Bridget, Soni Disha, Ingraham Cindy, Lee-Gosselin Audrey, Lamb Bruce T, Howell Gareth R, Carter Gregory W

Abstract excerpt

INTRODUCTION: Genome-wide association studies have identified over 70 genetic loci associated with late-onset Alzheimer's disease (LOAD), but few candidate polymorphisms have been functionally assessed for disease relevance and mechanism of action. METHODS: Candidate genetic risk variants were informatically prioritized and individually engineered into a LOAD-sensitized mouse model that carries the AD risk...

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Identifiers

PMID: 38687251
DOI: 10.1002/alz.13840
PMCID: PMC11247676

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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