Article

A novel systems biology approach to evaluate mouse models of late-onset Alzheimer’s disease

2019-06-26

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Late-onset Alzheimer’s disease (LOAD) is the most common form of dementia worldwide. To date, animal models of Alzheimer’s have focused on rare familial mutations, due to a lack of frank neuropathology from models based on common disease genes. Recent multi-cohort studies of postmortem human brain transcriptomes have identified a set of 30 gene co-expression modules associat...

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Literature Corpus work: 22bc288a-9577-58a2-a1f9-f77d624c21d8
DOI: 10.1101/682856

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