Article

<i>In vivo</i> validation of late-onset Alzheimer’s disease genetic risk factors

2023-12-24

Abstract excerpt

<h4>Structured Abstract</h4> <h4>Introduction</h4> Genome-wide association studies have identified over 70 genetic loci associated with late-onset Alzheimer’s disease (LOAD), but few candidate polymorphisms have been functionally assessed for disease relevance and mechanism of action. <h4>Methods</h4> Candidate genetic risk variants were informatically prioritized and individually engineered into a LOAD-sensiti...

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Literature Corpus work: fbf5f7bc-95be-5c11-98e0-539a3bfff17f
DOI: 10.1101/2023.12.21.572849

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