Article

Human Neonatal MR1T Cells Have Diverse TCR Usage, are Less Cytotoxic and are Unable to Respond to Many Common Childhood Pathogens

2025-04-01

Abstract excerpt

<title>Abstract</title> <p>Neonatal sepsis is a leading cause of childhood mortality. Understanding immune cell development can inform strategies to combat this. MR1-restricted T (MR1T) cells can be defined by their recognition of small molecules derived from microbes, self, and drug and drug-like molecules, presented by the MHC class 1-related molecule (MR1). In healthy adults, the majority of MR1T cells express...

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Literature Corpus work: d2d2a0fa-19f9-5aa9-a06d-6f4f8986b53a
DOI: 10.21203/rs.3.rs-6265058/v1

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