Article

BCG Vaccination at Birth Shapes the TCR Usage and Functional Profile of MR1T Cells at 9 Weeks of Age

2025-10-10

Abstract excerpt

Tuberculosis (TB) is the leading infectious disease killer worldwide and children suffer disproportionately. The ongoing burden of disease, despite widespread vaccination with BCG, highlights the need for novel vaccines. MR1-restricted T (MR1T) cells recognize small molecules, including microbial-derived molecules, presented by the monomorphic MHC class 1- related molecule (MR1). They have both “innate” effector c...

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Literature Corpus work: e2c6b92a-6262-51db-9402-6aff372b3fba
DOI: 10.1101/2025.10.09.681353

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