Article
Identification and Phenotype of MAIT Cells in Cattle and Their Response to Bacterial Infections.
Frontiers in immunology - 1 Jan 2021
Edmans Matthew D, Connelley Timothy K, Jayaraman Siddharth, Vrettou Christina, Vordermeier Martin, Mak Jeffrey Y W, Liu Ligong, Fairlie David P, Maze Emmanuel Atangana, Chrun Tiphany, Klenerman Paul, Eckle Sidonia B G, Tchilian Elma, Benedictus Lindert
Abstract excerpt
Mucosal-associated invariant T (MAIT) cells are a population of innate-like T cells that utilize a semi-invariant T cell receptor (TCR) α chain and are restricted by the highly conserved antigen presenting molecule MR1. MR1 presents microbial riboflavin biosynthesis derived metabolites produced by bacteria and fungi. Consistent with their ability to sense ligands derived from bacterial sources, MAIT cells have...
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