Article

Two types of human TCR differentially regulate reactivity to self and non-self antigens

2022-04-28

Abstract excerpt

<h4>SUMMARY</h4> Based on analyses of TCR sequences from over 1,000 individuals, we report that the TCR repertoire is composed of two ontogenically and functionally distinct types of TCRs. Their production is regulated by variations in thymic output and terminal deoxynucleotidyl transferase (TDT) activity. Neonatal TCRs derived from TDT-negative progenitors persist throughout life, are highly shared among subject...

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Literature Corpus work: 8492c10f-006f-54b4-8c49-4f21d02e5c53
DOI: 10.1101/2022.04.27.489747

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