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The CD4 − CD8 − MAIT cell subpopulation is a functionally distinct subset developmentally related to the main CD8 + MAIT cell pool

15 Nov 2018

Abstract excerpt

Significance Mucosa-associated invariant T (MAIT) cells are unconventional innate-like T cells recognizing microbial riboflavin metabolites presented by the monomorphic MR1 molecule. Here, we show that the CD8 + CD4 − and CD8 − CD4 − subpopulations of human MAIT cells represent transcriptionally and phenotypically discrete subsets with distinct functional profiles. Furthermore, T cell receptor repertoire...

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PMID: 30442667
DOI: 10.1073/pnas.1812273115

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