Article

Single-cell map of the healthy human immune system across the lifespan reveals unique infant immune signatures

2025-07-31

Abstract excerpt

The human immune system undergoes continuous remodeling from infancy through old age, yet the timing and trajectory of these changes across the lifespan remain poorly defined. To address this, we profiled peripheral blood mononuclear cells from 95 healthy individuals (ages 2 months to 88 years), including infants (n=27), children (n=23), adults (n=18), and older adults (n=27) using scRNA-seq and snATAC-seq. MAIT a...

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Literature Corpus work: 15eca355-7c82-55ba-afa5-6dfc6749c865
DOI: 10.1101/2025.07.28.667181

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