Article
Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance.
Nature communications - 1 Mar 2017
Davey Martin S, Willcox Carrie R, Joyce Stephen P, Ladell Kristin, Kasatskaya Sofya A, McLaren James E, Hunter Stuart, Salim Mahboob, Mohammed Fiyaz, Price David A, Chudakov Dmitriy M, Willcox Benjamin E
Abstract excerpt
γδ T cells are considered to be innate-like lymphocytes that respond rapidly to stress without clonal selection and differentiation. Here we use next-generation sequencing to probe how this paradigm relates to human Vδ2neg T cells, implicated in responses to viral infection and cancer. The prevalent Vδ1 T cell receptor (TCR) repertoire is private and initially unfocused in cord blood, typically becoming strongly...
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