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Article

Dynamics of Individual T Cell Repertoires: From Cord Blood to Centenarians

14 May 2016

Abstract excerpt

The diversity, architecture, and dynamics of the TCR repertoire largely determine our ability to effectively withstand infections and malignancies with minimal mistargeting of immune responses. In this study, we have employed deep TCRβ repertoire sequencing with normalization based on unique molecular identifiers to explore the long-term dynamics of T cell immunity. We demonstrate remarkable stability of...

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PMID: 27183615
DOI: 10.4049/jimmunol.1600005

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