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Article

Ontogeny of human mucosal-associated invariant T cells and related T cell subsets

16 Jan 2018

Abstract excerpt

Mucosal-associated invariant T (MAIT) cells are semi-invariant Vα7.2+ CD161highCD4− T cells that recognize microbial riboflavin precursor derivatives such as 5-OP-RU presented by MR1. Human MAIT cells are abundant in adult blood, but there are very few in cord blood. We longitudinally studied Vα7.2+ CD161high T cell and related subset levels in infancy and after cord blood transplantation. We show that Vα7.2+ and...

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PMID: 29339446
DOI: 10.1084/jem.20171739

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