Article

3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibility

2024-08-12

Abstract excerpt

<h4>ABSTRACT</h4> Genome-wide association studies (GWAS) have identified genetic links to autoimmune disorders, but lack detail on causal elements. We generated 3D genomic datasets of promoter-focused Capture-C, Hi-C, ATAC-seq, and RNA-seq across 57 human cell types integrated with GWAS of 16 autoimmune traits. These data allowed us to map disease-associated variants to their effector genes and identify impacted...

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Literature Corpus work: 855e3980-24be-5925-aa62-43f1a2ef7330
DOI: 10.1101/2024.08.12.24311676

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