Article

Genetic regulation of cell type–specific chromatin accessibility shapes immune function and disease risk

2025-08-29

Abstract excerpt

Understanding how genetic variation influences gene regulation at the single-cell level is crucial for elucidating the mechanisms underlying complex diseases. However, limited large-scale single-cell multi-omics data have constrained our understanding of the regulatory pathways linking variants to cell type-specific gene expression. Here we present chromatin accessibility profiles from 3.5 million peripheral blood...

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Identifiers and source

Literature Corpus work: a617af48-e18c-5496-ab88-a46744c91090
DOI: 10.1101/2025.08.27.25334533

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