Article
3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibility.
Genome biology - 8 Dec 2025
Trang Khanh B, Sharma Prabhat, Cook Laura, Mount Zachary, Thomas Rajan M, Kulkarni Nikhil N, Cabrera Emylette Cruz, Rachimi Suzanna, Pahl Matthew C, Pippin James A, Su Chun, Kaestner Klaus H, O'Brien Joan M, Wagley Yadav, Hankenson Kurt D, Jermusyk Ashley, Hoskins Jason W, Amundadottir Laufey T, Xu Mai, Brown Kevin M, Anderson Stewart A, Yang Wenli, Titchenell Paul M, Seale Patrick, Zemel Babette S, Chesi Alessandra, Romberg Neil, Levings Megan K, Grant Struan F A, Wells Andrew D
Abstract excerpt
BACKGROUND: Insight into the genetic basis for many common autoimmune disorders has been uncovered by genome-wide association studies (GWAS), but this alone does not reveal causal variants, effector genes, or the cell types impacted by disease-associated variation. RESULTS: Here, we generate 3D genomic datasets consisting of promoter-focused Capture-C, Hi-C, ATAC-seq, and RNA-seq and integrate this data with GWAS...
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