Article

Phosphorylation by CK2 Regulates MUS81/EME1 in Mitosis and After Replication Stress

2018-03-07

Abstract excerpt

<h4>ABSTRACT</h4> The MUS81 complex is crucial for preserving genome stability through the resolution of branched DNA intermediates in mitosis. However, untimely activation of the MUS81 complex in S-phase is dangerous. Little is known about the regulation of the human MUS81 complex and how deregulated activation affects chromosome integrity. Here, we show that the CK2 kinase phosphorylates MUS81 at Serine 87 in l...

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Literature Corpus work: d2c4720b-b724-5699-aab1-947ec07b2d8d
DOI: 10.1101/278143

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