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Article

Cell cycle-dependent regulation of the nuclease activity of Mus81-Eme1/Mms4.

Nucleic acids research - 1 Sept 2012

Gallo-Fernández María, Saugar Irene, Ortiz-Bazán María Ángeles, Vázquez María Victoria, Tercero José Antonio

Abstract excerpt

The conserved heterodimeric endonuclease Mus81-Eme1/Mms4 plays an important role in the maintenance of genomic integrity in eukaryotic cells. Here, we show that budding yeast Mus81-Mms4 is strictly regulated during the mitotic cell cycle by Cdc28 (CDK)- and Cdc5 (Polo-like kinase)-dependent phosphorylation of the non-catalytic subunit Mms4. The phosphorylation of this protein occurs only after bulk DNA synthesis...

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Identifiers

PMID: 22730299
DOI: 10.1093/nar/gks599
PMCID: PMC3458551

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Cell cycle-dependent regulation of the nuclease activity of Mus81-Eme1/Mms4.PMID 22730299Read ↗

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