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Article

Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease.

The Journal of cell biology - 22 Aug 2011

Domínguez-Kelly Raquel, Martín Yusé, Koundrioukoff Stephane, Tanenbaum Marvin E, Smits Veronique A J, Medema René H, Debatisse Michelle, Freire Raimundo

Abstract excerpt

Correct replication of the genome and protection of its integrity are essential for cell survival. In a high-throughput screen studying H2AX phosphorylation, we identified Wee1 as a regulator of genomic stability. Wee1 down-regulation not only induced H2AX phosphorylation but also triggered a general deoxyribonucleic acid (DNA) damage response (DDR) and caused a block in DNA replication, resulting in accumulation...

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Identifiers

PMID: 21859861
DOI: 10.1083/jcb.201101047
PMCID: PMC3160579

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Related research

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Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease.PMID 21859861Read ↗

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