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Article

Replication checkpoint kinase Cds1 regulates Mus81 to preserve genome integrity during replication stress.

Genes & development - 15 Apr 2005

Kai Mihoko, Boddy Michael N, Russell Paul, Wang Teresa S-F

Abstract excerpt

The replication checkpoint kinase Cds1 preserves genome integrity by stabilizing stalled replication forks. Cds1 targets substrates through its FHA domain. The Cds1 FHA domain interacts with Mus81, a subunit of the Mus81-Eme1 structure-specific endonuclease. We report here that Mus81 and Rhp51 are required for generating deletion mutations in fission yeast replication mutants that experience replication stress. A...

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Identifiers

PMID: 15805465
DOI: 10.1101/gad.1304305
PMCID: PMC1080131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Related research

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Replication checkpoint kinase Cds1 regulates Mus81 to preserve genome integrity during replication stress.PMID 15805465Read ↗

Active Replication Checkpoint Drives Genome Instability in Fission Yeast mcm4 Mutant.Semantic proximity Read ↗

Cleavage of stalled forks by fission yeast Mus81/Eme1 in absence of DNA replication checkpoint.Semantic proximity Read ↗

Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease.Semantic proximity Read ↗

CHK2 regulates MUS81-dependent DSBs in response to replication stress and BRCA2 deficiencySemantic proximity Read ↗

Cds1 controls the release of Cdc14-like phosphatase Flp1 from the nucleolus to drive full activation of the checkpoint response to replication stress in fission yeast.Semantic proximity Read ↗

Mus81 functions in the quality control of replication forks at the rDNA and is involved in the maintenance of rDNA repeat number in Saccharomyces cerevisiae.Semantic proximity Read ↗

FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress.Semantic proximity Read ↗

Mus81 is essential for sister chromatid recombination at broken replication forks.Semantic proximity Read ↗

Mus81, Rhp51(Rad51), and Rqh1 form an epistatic pathway required for the S-phase DNA damage checkpoint.Semantic proximity Read ↗

Phosphorylation by CK2 Regulates MUS81/EME1 in Mitosis and After Replication StressSemantic proximity Read ↗

Cid1, a fission yeast protein required for S-M checkpoint control when DNA polymerase delta or epsilon is inactivated.Semantic proximity Read ↗

Cell cycle-dependent regulation of the nuclease activity of Mus81-Eme1/Mms4.Semantic proximity Read ↗

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