Article
A cell cycle-regulated Slx4-Dpb11 complex promotes the resolution of DNA repair intermediates linked to stalled replication.
Genes & development - 15 Jul 2014
Gritenaite Dalia, Princz Lissa N, Szakal Barnabas, Bantele Susanne C S, Wendeler Lina, Schilbach Sandra, Habermann Bianca H, Matos Joao, Lisby Michael, Branzei Dana, Pfander Boris
Abstract excerpt
A key function of the cellular DNA damage response is to facilitate the bypass of replication fork-stalling DNA lesions. Template switch reactions allow such a bypass and involve the formation of DNA joint molecules (JMs) between sister chromatids. These JMs need to be resolved before cell division; however, the regulation of this process is only poorly understood. Here, we identify a regulatory mechanism in...
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