Article

The CDK Pef1 and Protein Phosphatase 4 oppose each other for regulating cohesin binding to fission yeast chromosomes

2019-08-28

Abstract excerpt

<h4>ABSTRACT</h4> Cohesin has essential roles in chromosome structure, segregation and repair. Cohesin binding to chromosomes is catalyzed by the cohesin loader, Mis4 in fission yeast. How cells fine tune cohesin deposition is largely unknown. Here we provide evidence that Mis4 activity is regulated by phosphorylation of its cohesin substrate. A genetic screen for negative regulators of Mis4 yielded a CDK called...

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Literature Corpus work: 4dcbb415-a184-51dd-965e-83219a7802ed
DOI: 10.1101/748855

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