Article

CHK2 regulates MUS81-dependent DSBs in response to replication stress and BRCA2 deficiency

2022-10-08

Abstract excerpt

<h4>ABSTRACT</h4> MUS81 is a structure-specific endonuclease that processes DNA intermediates in mitosis and in S-phase following replication stress. MUS81 is crucial to cleave deprotected reversed forks in BRCA2-deficient cells. However, how MUS81 is regulated during replication stress in human cells remains unknown. Our study reveals that CHK2 binds the MUS81-EME2 complex and positively regulates formation of D...

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Literature Corpus work: 05aaf76e-0349-5632-b1ce-4ea82fe45e09
DOI: 10.1101/2022.10.08.511087

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