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On Broken Ne(c)ks and Broken DNA: The Role of Human NEKs in the DNA Damage Response

27 Feb 2021

Abstract excerpt

NIMA-related kinases, or NEKs, are a family of Ser/Thr protein kinases involved in cell cycle and mitosis, centrosome disjunction, primary cilia functions, and DNA damage responses among other biological functional contexts in vertebrate cells. In human cells, there are 11 members, termed NEK1 to 11, and the research has mainly focused on exploring the more predominant roles of NEKs in mitosis regulation and cell...

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PMID: 33673578
DOI: 10.3390/cells10030507

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