Article

DDK has a primary role in processing stalled replication forks to initiate downstream checkpoint signaling

2017-10-21

Abstract excerpt

CDC7-DBF4 kinase (DDK) is required to initiate DNA replication in eukaryotes by activating the replicative MCM helicase. DDK has also been reported to have diverse and sometimes conflicting roles in the replication checkpoint response in various organisms but the underlying mechanisms are far from settled. Here we show that human DDK promotes limited resection of newly synthesized DNA at stalled replication forks...

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Literature Corpus work: 5ec1df31-da3a-537c-8c1e-3b60716838d7
DOI: 10.1101/207266

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