Article

Gene expression is globally regulated by interacting nucleobase supply and mRNA composition demand: a mechanism disrupted by multiple disease states and drug treatments

2024-12-23

Abstract excerpt

Conventional expression studies quantify messenger RNA (mRNA) transcript levels gene-by-gene. We recently showed that protein expression is modulated at a global scale by amino acid availability, suggesting that mRNA expression levels might be similarly affected by nucleobase supply. Re-analysis of transcriptomic datasets confirmed that nucleobase supply and mRNA A+U:C+G sequence composition interact to shape a gl...

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Literature Corpus work: d2ab338a-eaca-529b-a8e9-71165b9311b9
DOI: 10.1101/2024.12.23.630131

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