Article

Metabolism of epigenetic ribonucleosides leads to nucleolar stress and cytotoxicity

2025-06-13

Abstract excerpt

<h4>ABSTRACT</h4> Post-transcriptional RNA modifications are ubiquitous in biology, but the fate of epigenetic ribonucleotides after RNA turnover and the consequences of their metabolism and misincorporation into nucleic acids are largely unknown. Here we explore the metabolism of epigenetic ribonucleosides in human cells by studying effects on cell growth, quantifying misincorporation into cellular RNAs and iden...

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Literature Corpus work: 2ce48605-48d5-52bf-a3bb-0d7778583b25
DOI: 10.1101/2025.06.11.659152

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