Reprogramming neuroblastoma by diet-enhanced polyamine depletion

Abstract excerpt

<h4>Summary</h4> Neuroblastoma is a highly lethal childhood tumor derived from differentiation-arrested neural crest cells 1,2 . Like all cancers, its growth is fueled by metabolites obtained from either circulation or local biosynthesis 3,4 . Neuroblastomas depend on local polyamine biosynthesis, with the inhibitor difluoromethylornithine showing clinical activity 5 . Here we show that such inhibition can be...

Topics

Open a Topic to create a Post that cites this publication.

• Autophagy in Disease and Therapy
• Cancer, Hypoxia, and Metabolism
• Epigenetics and DNA Methylation
• Glioma Diagnosis and Treatment
• Ion channel regulation and function
• Neuroblastoma Research and Treatments
• Pancreatic function and diabetes
• Polyamine Metabolism and Applications

Identifiers and source

Literature Corpus work

b95020d6-fce3-598a-9443-cdb0dd06773a

DOI

10.1101/2024.01.07.573662