Article

Decoding m6Am by simultaneous transcription-start mapping and methylation quantification

2025-03-31

Abstract excerpt

N 6 ,2’- O -dimethyladenosine (m 6 Am) is a modified nucleotide located at the first transcribed position in mRNA and snRNA that is essential for diverse physiological processes. m 6 Am mapping methods assume each gene uses a single start nucleotide. However, gene transcription usually involves multiple start sites, generating numerous 5’ isoforms. Thus, gene-level annotations cannot capture the diversity of m 6 A...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cfeaf7ff-c2e1-531f-9713-e8bb1aedf72b
DOI: 10.7554/elife.104139.3

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Decoding m6Am by simultaneous transcription-start mapping and methylation quantificationDOI 10.7554/elife.104139.3Read

Decoding m <sup>6</sup> Am by simultaneous transcription-start mapping and methylation quantificationSemantic proximity Read

m6A-mRNA methylation regulates cardiac gene expression and cellular growthSemantic proximity Read

Advanced eTAM-seq enables high-fidelity, low-input <i>N</i> <sup>6</sup> -methyladenosine profiling in human cells and embryonic mouse tissuesSemantic proximity Read

Comprehensive analysis across mammalian tissues and cells decipher the underlying mechanism of m6A specificitySemantic proximity Read

m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells.Semantic proximity Read

Systematic identification of tissue-conserved m <sup>6</sup> A sites reveals a stable epitranscriptomic regulatory layer controlling essential genesSemantic proximity Read

Single-Molecule Direct RNA Sequencing Reveals the Shaping of Epitranscriptome Across Multiple SpeciesSemantic proximity Read

Comprehensive profiling of <i>N</i> <sup>6</sup> -methyladnosine (m <sup>6</sup> A) readouts reveals novel m <sup>6</sup> A readers that regulate human embryonic stem cell differentiationSemantic proximity Read

Detection of differential RNA modifications from direct RNA sequencing of human cell linesSemantic proximity Read

Allele-specific RNA N 6-methyladenosine modifications reveal functional genetic variants in human tissues.Semantic proximity Read

N6-Methyladenosine Role in Cancer: Learning from AMLSemantic proximity Read

Base-resolution mapping reveals distinct m <sup>1</sup> A methylome in nuclear- and mitochondrial-encoded transcriptsSemantic proximity Read