Inter-organellar nucleic acid communication by a mitochondrial tRNA regulates nuclear metabolic transcription

Abstract excerpt

<h4>SUMMARY</h4> Efficient communication between mitochondria and the nucleus underlies homoeostatic metabolic control, though the involved mitochondrial factors and their mechanisms are poorly defined. Here, we report the surprising detection of multiple mitochondrial-derived transfer RNAs (mito-tRNAs) within the nuclei of human cells. Focused studies of nuclear-transported mito-tRNA-asparagine (mtAsn) revealed...

Topics

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• Amino Acyl-tRNA Synthetases
• MELAS Syndrome
• Mitochondrial Diseases
• Oxidative Phosphorylation
• RNA, Mitochondrial
• RNA modifications and cancer
• RNA Processing, Post-Transcriptional
• RNA, Transfer

Identifiers and source

Literature Corpus work

86446f0a-878d-5a62-bf45-f02099013946

DOI

10.1101/2023.09.21.558912