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Article

Alternative Splicing in the Nuclear Receptor Superfamily Expands Gene Function to Refine Endo-Xenobiotic Metabolism.

Drug metabolism and disposition: the biological fate of chemicals - 1 Apr 2020

Annalora Andrew J, Marcus Craig B, Iversen Patrick L

Abstract excerpt

The human genome encodes 48 nuclear receptor (NR) genes, whose translated products transform chemical signals from endo-xenobiotics into pleotropic RNA transcriptional profiles that refine drug metabolism. This review describes the remarkable diversification of the 48 human NR genes, which are potentially processed into over 1000 distinct mRNA transcripts by alternative splicing (AS). The average human NR...

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PMID: 31980501
DOI: 10.1124/dmd.119.089102

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