Article

Deficiency of ZC3HC1 modulates vascular smooth muscle cell phenotype and increases neointima formation

2021-10-01

Abstract excerpt

The ZC3HC1 gene has been linked to various cardiovascular traits. One variant, rs11556924-T, has been found to lower the risk of coronary artery disease (CAD) and blood pressure, but increases carotid intima-media thickness (IMT). This study aimed to determine how ZC3HC1 affects IMT using in vitro and in vivo models. In this study, we analyzed the effect of the rs11556924-T allele on ZC3HC1 expression in vascular...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d2809395-e3d7-5f3c-aa92-c900c8422cb7
DOI: 10.1101/2021.09.29.462212

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deficiency of ZC3HC1 modulates vascular smooth muscle cell phenotype and increases neointima formationDOI 10.1101/2021.09.29.462212Read

Deficiency of ZC3HC1 Modulates Vascular Smooth Muscle Cell Phenotype and Increases Neointima Formation.Semantic proximity Read

Functional Validation of a Common Nonsynonymous Coding Variant in ZC3HC1 Associated With Protection From Coronary Artery Disease.Semantic proximity Read

BACH1 deficiency prevents neointima formation and maintains the differentiated phenotype of vascular smooth muscle cells by regulating chromatin accessibility.Semantic proximity Read

CASC15 dictates vascular smooth muscle cell growth fate and pathological vascular remodeling through post-transcription regulation of mitotic fidelitySemantic proximity Read

Suv39h1 Regulates Phenotypic Modulation of Smooth Muscle Cells and Contributes to Vascular Injury by Repressing HIC1 Transcription.Semantic proximity Read

<i>Smad3</i> Regulates Smooth Muscle Cell Fate and Governs Adverse Remodeling and Calcification of Atherosclerotic PlaqueSemantic proximity Read

Coronary Artery Disease Risk Gene <i>PRDM16</i> is Preferentially Expressed in Vascular Smooth Muscle Cells and a Potential Novel Regulator of Smooth Muscle HomeostasisSemantic proximity Read

SMYD2 Regulates Vascular Smooth Muscle Cell Phenotypic Switching and Intimal Hyperplasia via Interaction with MyocardinSemantic proximity Read

Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease riskSemantic proximity Read

Smad3 Regulates Smooth Muscle Cell Fate and Governs Adverse Remodeling and Calcification of Atherosclerotic PlaqueSemantic proximity Read

Coronary artery disease risk gene PRDM16 regulates smooth muscle homeostasis.Semantic proximity Read

Leiomodin 1 haploinsufficiency promotes smooth muscle cell proliferation and increases neointimal lesion size.Semantic proximity Read