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Article

Suv39h1 Regulates Phenotypic Modulation of Smooth Muscle Cells and Contributes to Vascular Injury by Repressing HIC1 Transcription.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2025

Yang Yuyu, Zhang Qiumei, Liu Shuai, Yuan Haihang, Wu Xiaoping, Zou Yi, Zhang Yuanyuan, Guo Junli

Abstract excerpt

BACKGROUND: Vascular smooth muscle cells (VSMCs), in response to a myriad of injurious stimuli, switch from a contractile state to a proliferative/migratory state in a process known as phenotypic modulation. Phenotypic modulation of VSMCs contributes to neointima formation and underscores a host of vascular pathologies, including atherosclerosis. In the present study, we investigated the involvement of Suv39h1...

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Share to Carotid Artery Injuries
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kruppel-Like Transcription Factors

Share to Methyltransferases

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Neointima

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Source

Open in PubMed Open full text

Identifiers

PMID: 40308197
DOI: 10.1161/ATVBAHA.124.322048
PMCID: PMC12094260

Genes

HIC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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