FHL3 Regulates Vascular Smooth Muscle Cell Phenotypic Switching Through the MRTFB-SRF Signaling Axis.

Abstract excerpt

Genome-wide association studies have uncovered many coronary artery disease (CAD) loci, but mechanisms linking risk variants to vascular biology remain unclear. We screen candidate causal CAD genes for regulators of the vascular smooth muscle cell (VSMC) contractile phenotype using a pooled CRISPR-Cas9 knockout library in primary human VSMCs with MYH11 protein levels as the readout. FHL3 (four-and-a-half LIM...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Coronary Artery Disease
• Share to Intracellular Signaling Peptides and Proteins
• Share to LIM Domain Proteins