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Article

Deficiency of ZC3HC1 Modulates Vascular Smooth Muscle Cell Phenotype and Increases Neointima Formation.

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2026

Aherrahrou Redouane, Reinberger Tobias, Werner Julia, Otto Miriam, Al-Hasani Jaafar, Munoz-Venegas Maria Loreto, Yin Xiaoke, Mayr Manuel, Civelek Mete, Schunkert Heribert, Kessler Thorsten, Aherrahrou Zouhair

Abstract excerpt

BACKGROUND: The ZC3HC1 (zinc finger C3HC-type containing 1) gene has been linked to various cardiovascular traits, including coronary artery disease, blood pressure, and carotid intima-media thickness with opposing effects. This study aimed to investigate the role of ZC3HC1 in smooth muscle cell (SMC) biology and its contribution to neointima formation. METHODS: SMC phenotypes (proliferation and migration) were...

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Cell Cycle Proteins
Cell Movement
Cell Proliferation
Cyclin B1
Mice, Knockout

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscle, Smooth, Vascular

Myocytes, Smooth Muscle

Source

Identifiers

PMID: 41815085
DOI: 10.1161/ATVBAHA.125.323659

Genes

ZC3HC1
CCNB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Deficiency of ZC3HC1 Modulates Vascular Smooth Muscle Cell Phenotype and Increases Neointima Formation.PMID 41815085Read ↗

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