Article

CASC15 dictates vascular smooth muscle cell growth fate and pathological vascular remodeling through post-transcription regulation of mitotic fidelity

2026-06-30

Abstract excerpt

<h4>ABSTRACT</h4> Vascular smooth muscle cell (SMC) growth, whether hyperplastic or hypertrophic, is a central determinant of vascular remodeling in cardiovascular disease, yet the molecular regulators that direct SMC toward a specific growth fate remain poorly understood. Here, we identify the long non-coding RNA CASC15 as a critical regulator of SMC growth and vascular remodeling. CASC15 is enriched in the vasc...

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Literature Corpus work: 9d929ad3-04a5-55b7-858f-1da9cc57e3ae
DOI: 10.64898/2026.06.29.735301

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