Article
BACH1 deficiency prevents neointima formation and maintains the differentiated phenotype of vascular smooth muscle cells by regulating chromatin accessibility.
Nucleic acids research - 22 May 2023
Guo Jieyu, Qiu Jingjing, Jia Mengping, Li Qinhan, Wei Xiangxiang, Li Liliang, Pan Qi, Jin Jiayu, Ge Fei, Ma Siyu, He Yunquan, Lin Jiayi, Li Yongbo, Ma Jinghua, Jiang Nan, Zhi Xiuling, Jiang Lindi, Zhang Jianyi, Osto Elena, Jing Qing, Wang Xinhong, Meng Dan
Abstract excerpt
The transcription factor BTB and CNC homology 1(BACH1) has been linked to coronary artery disease risk by human genome-wide association studies, but little is known about the role of BACH1 in vascular smooth muscle cell (VSMC) phenotype switching and neointima formation following vascular injury. Therefore, this study aims to explore the role of BACH1 in vascular remodeling and its underlying mechanisms. BACH1...
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