Article
Functional Validation of a Common Nonsynonymous Coding Variant in ZC3HC1 Associated With Protection From Coronary Artery Disease.
Circulation. Cardiovascular genetics - 1 Jan 2017
Linseman Tara, Soubeyrand Sébastien, Martinuk Amy, Nikpay Majid, Lau Paulina, McPherson Ruth
Abstract excerpt
BACKGROUND: Although virtually all coronary artery disease associated single-nucleotide polymorphisms identified by genome-wide association studies (GWAS) are in noncoding regions of the genome, a common polymorphism in ZC3HC1 (rs11556924), resulting in an arginine (Arg) to histidine (His) substitution in its encoded protein, NIPA (Nuclear Interacting Partner of Anaplastic Lyphoma Kinase) is linked to a...
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