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Defining early changes in Alzheimer’s disease from RNA sequencing of brain regions differentially affected by pathology

1 Mar 2021

Abstract excerpt

Tau pathology in Alzheimer's disease (AD) spreads in a predictable pattern that corresponds with disease symptoms and severity. At post-mortem there are cortical regions that range from mildly to severely affected by tau pathology and neuronal loss. A comparison of the molecular signatures of these differentially affected areas within cases and between cases and controls may allow the temporal modelling of...

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PMID: 33649380
DOI: 10.1038/s41598-021-83872-z

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