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Novel Pathological Mechanisms Revealed by Spatial Transcriptomic Analysis of Hippocampus in Aged Control, Primary Age-Related Tauopathy, and Alzheimer’s Disease

2025-08-22

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<title>Abstract</title> <p>While both Primary Age-Related Tauopathy (PART) and Alzheimer’s Disease (AD) involve the accumulation of hyperphosphorylated tau (pTau)-positive neurofibrillary tangles (NFTs) in the hippocampus, PART is distinguished by the absence of β-amyloid (Aβ) deposition and is generally associated with milder cognitive impairment than AD. To delineate cellular and molecular mechanisms that are c...

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Literature Corpus work
91f903d6-d9c6-52a2-ba64-4f259363574f
DOI
10.21203/rs.3.rs-7303622/v1
Open publication

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Novel Pathological Mechanisms Revealed by Spatial Transcriptomic Analysis of Hippocampus in Aged Control, Primary Age-Related Tauopathy, and Alzheimer’s DiseaseDOI 10.21203/rs.3.rs-7303622/v1
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