Article

Lineage tracing of human embryonic development and foetal haematopoiesis through somatic mutations

2020-05-30

Abstract excerpt

To date, ontogeny of the human haematopoietic system during foetal development has been characterized mainly through careful microscopic observations. Here we used whole-genome sequencing (WGS) of 511 single-cell derived haematopoietic colonies from healthy human foetuses of 8 and 18 post-conception weeks (pcw) coupled with deep targeted sequencing of tissues of known embryonic origin to reconstruct a phylogenetic...

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Literature Corpus work: d2099aac-ad91-5bf7-bf39-30ca47ac1129
DOI: 10.1101/2020.05.29.088765

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