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Article

Lineage tracing of human development through somatic mutations.

Nature - 1 Jul 2021

Spencer Chapman Michael, Ranzoni Anna Maria, Myers Brynelle, Williams Nicholas, Coorens Tim H H, Mitchell Emily, Butler Timothy, Dawson Kevin J, Hooks Yvette, Moore Luiza, Nangalia Jyoti, Robinson Philip S, Yoshida Kenichi, Hook Elizabeth, Campbell Peter J, Cvejic Ana

Abstract excerpt

The ontogeny of the human haematopoietic system during fetal development has previously been characterized mainly through careful microscopic observations1. Here we reconstruct a phylogenetic tree of blood development using whole-genome sequencing of 511 single-cell-derived haematopoietic colonies from healthy human fetuses at 8 and 18 weeks after conception, coupled with deep targeted sequencing of tissues of...

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Identifiers

PMID: 33981037
DOI: 10.1038/s41586-021-03548-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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